Microcapsules prepared with biodegradable polymer for prolonged release of drugs.

Polymer microcapsules with programmable active release.

We present a new type of microcapsule programmed with a tunable active release mechanism. The capsules are triggered by a plasticizing stimulus that induces a phase change transition of the polymeric membrane from a solid to a fluidized form; thereafter, the cargo is actively driven out of the capsule through a defect at the capsule wall with controllable release kinetics. Tuning the degree of ...

Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

pH-controlled drug loading and release from biodegradable microcapsules.

Microcapsules made of biopolymers are of both scientific and technological interest and have many potential applications in medicine, including their use as controlled drug delivery devices. The present study makes use of the electrostatic interaction between polycations and polyanions to form a multilayered microcapsule shell and also to control the loading and release of charged drug molecule...

Biodegradable Polymer Microneedles for Controlled-release Drug Delivery

Biopharmaceuticals, which include proteins, DNA, vaccines and other biologically related molecules, make up one of the fastest growing segments of the overall pharmaceutical market. However, there are significant delivery limitations. Specifically, oral delivery is difficult due to Poor absorption and degradation that occurs in the GI tract and liver and more sensitive drugs including proteins ...

Evaluation of the Effect of Hydrophilic Polymer Blend to Extend the Release of Clarithromycin from Prepared Microcapsules

Whether the control of oral absorption is desired or the delivery of genes to the interior of specific cellsis sought the drug delivery macromolecule has emerged the most ubiquitous entity. In the current volume, macromolecules and their “younger (and sometimes smaller) cousins,” dendrimers, are presented as components extraordinaire of a variety of drug delivery systems. The therapeutic effect...